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KMID : 0360220210620040531
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Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 4 p.531 ~ p.537
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Effect and Safety of Travoprost 0.003% in Open Angle Glaucoma
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Sung Su-Min
Kim Jong-Heon
Lee Chong-Eun
Lee Kyoo-Won
Seo Sam
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Abstract
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Purpose: To determine whether travoprost 0.003% has a similar intraocular pressure (IOP) reduction effect to that of travoprost0.004% while reducing side effects.
Methods: This was a prospective study from January 2018 to December 2018 that included 102 patients diagnosed with openangle glaucoma who switched from travoprost 0.004% to travoprost 0.003%. We investigated the changes in IOP, conjunctivalhyperemia, corneal erosion, and eyelid pigmentation before and at 3 months after switching to travoprost 0.003%. Additionally,a questionnaire survey of these patients was conducted to determine possible side effects, including hyperemia, stinging, pruritus,irritation, blurred vision, dryness, and foreign body sensation.
Results: IOP readings before and after switching to travoprost 0.003% were 12.95 ± 4.25 and 12.94 ± 3.89 mmHg, respectively,showing no significant change (p = 0.974). No changes were observed in corneal erosion or eyelid pigmentation; however, conjunctivalhyperemia was reduced significantly from 1.60 ± 0.88 to 1.36 ± 0.84 (p = 0.001). No significant changes in hyperemia,stinging, pruritus, irritation, or foreign body sensation were reported; however, a significant improvement was noted for blurredvision and dryness (p = 0.008, p = 0.007, respectively).
Conclusions: We were able to show the effectiveness and safety of travoprost 0.003% as being as effective as travoprost0.004% in reducing IOP and injections while improving blurred vision and dryness.
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KEYWORD
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Hyperemia, Intraocular pressure, Open angle glaucoma, Travoprost
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